I’m on HRT and taking Mounjaro – what do I need to know?

Important

Please read the information below carefully if you are using both Mounjaro and a Contraceptive.  If you feel this applies to you or would like to discuss further, please contact the surgery.

What are GLP-1 agonists?

GLP-1 agonists are medicines like tirzepatide and semaglutide. They might have other brand names too. These medicines can only be given by a doctor or nurse. They are used for people with type 2 diabetes or to help with losing weight. They work by making food leave the stomach more slowly.

Medication

Brand name examples

Tirzepatide

Mounjaro

Semaglutide

Ozempic, Wegovy, Rybelsus

Exenatide

Bydureon BCise

Liraglutide

Saxenda, Diavic, Victoza

Dulaglutide

Trulicity

Lixisenatide

Contained in Suliqua

If you are taking oral progestogen as part of your HRT (for example Utrogestan, Norethisterone, Medroxyprogesterone), then you need to be aware that tirzepatide (Mounjaro) may have an impact on the effectiveness of your HRT. This means your HRT might not protect your endometrium (womb lining) enough. Please contact the surgery to book an HRT review, as we may need to increase your dose or change you to a different form of medication.

If you do not take your HRT orally (for example, you use a patch, a gel or a Mirena coil instead of a tablet) then you do not need to worry.

This patient information is based on a leaflet from the Faculty of Sexual and Reproductive Healthcare (FSRH) and the Primary Care Women’s Health Society.     

Page last reviewed: 03 October 2025
Page created: 03 October 2025